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KMID : 1149120190160020059
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Journal of the Korean Society for Psoriasis
2019 Volume.16 No. 2 p.59 ~ p.63
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A Case of Refractory Psoriasis to Ustekinumab and Guselkumab Treatment
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Sohng Chi-Hyeon
Park Kyung-Duck
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Abstract
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A 25-year-old man, who was suffered from plaque psoriasis for over 6 years, visited our medical center. He did not respond to previous treatments of conventional therapies, including acitretin, cyclosporine and methotrexate, and ustekinumab. He newly started guselkumab (100mg at week 0 and 4, then 100mg at every 8 weeks in total five injections), but it showed insufficient efficacy. The authors considered switching to ixekizumab and after three injections of ixekizumab (80mg every two weeks with a starting dose of 160mg at week 0), the patients appeared to be mostly improved lesions. Biologics have been established the superior efficacy in patients with moderate- to-severe psoriasis. However, some patients show little efficacy from the beginning or lowered efficacy after successful maintenance. In those cases, experts may consider treatment switching, but there are no evidence-based studies on switching biologics in psoriasis. Herein, we report a case of refractory psoriasis to multiple biologics.
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KEYWORD
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Biologics, Guselkumab, Ixekizumab, Switching, Ustekinumab
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